Pivotal role of pericytes in kidney fibrosis
نویسندگان
چکیده
منابع مشابه
Hypoxia and fibrosis in chronic kidney disease: crossing at pericytes
Chronic kidney disease (CKD) is placing an increasing burden on patients and societies because no decisive therapy has been established. Tubulointerstitial lesions accompanied by fibrosis, inflammatory cells, and capillary rarefaction not only characterize, but also aggravate renal dysfunction in CKD. In this setting, renal cells, particularly tubular cells, suffer from hypoxia caused by the im...
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15 صفحه اولHuman kidney pericytes produce renin
Pericytes, perivascular cells embedded in the microvascular wall, are crucial for vascular homeostasis. These cells also play diverse roles in tissue development and regeneration as multi-lineage progenitors, immunomodulatory cells and as sources of trophic factors. Here, we establish that pericytes are renin producing cells in the human kidney. Renin was localized by immunohistochemistry in CD...
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ژورنال
عنوان ژورنال: Clinical and Experimental Pharmacology and Physiology
سال: 2011
ISSN: 0305-1870
DOI: 10.1111/j.1440-1681.2011.05531.x